rho-Associated Kinases

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Also Known As:

ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha; p160ROCK; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho-Associated Coiled-Coil Kinase; rho-Associated Kinase 1; rho-Associated Kinase 2; rho-Associated Kinase alpha; rho-Associated Kinase beta; rho-Associated Protein Kinase alpha; rho-Associated Protein Kinase beta; rho-Kinase; Coiled-Coil Kinase, rho-Associated; Protein Kinases, ROCK; ROCK I Protein Kinase; ROCK II Protein Kinase; p160 rhoA Binding Kinase ROKalpha; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 2; rho Associated Coiled Coil Kinase; rho Associated Kinase; rho Associated Kinase 1; rho Associated Kinase 2; rho Associated Kinase alpha; rho Associated Kinase beta; rho Associated Kinases; rho Associated Protein Kinase alpha; rho Associated Protein Kinase beta; rho Kinase; rho-Associated Kinase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein Serine-Threonine Kinases: 3707
        rho-Associated Kinases: 2071
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3707
      - rho-Associated Kinases: 2071

Spencer Su Selected Research

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Disease

Drug/Important Bio-Agent (IBA)